Your genome isn’t just personal data—it’s a national asset. As precision medicine goes global, countries are confronting a critical challenge: how to harness cloud-powered genomics while preventing sensitive DNA data from crossing borders. Sovereign cloud systems are emerging as the solution, offering nations the computational muscle to process millions of genomes without surrendering control. These secure architectures enable breakthroughs—like Japan’s AI-driven cancer variant research on domestically stored data or Estonia’s population-wide disease prevention programs—while adhering to strict biosecurity and privacy laws. From air-gapped supercomputers analyzing indigenous populations’ unique genetic markers to federated learning systems that advance global research without raw data exchange, we explore how genomic sovereignty is reshaping healthcare’s future. The message is clear: in the era of DNA-driven medicine, data locality isn’t just about compliance—it’s about preserving national health security in the biotechnology age.
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